HCAR2 抗体 (Middle Region)
This anti-HCAR2 antibody is a 兔 多克隆 antibody detecting HCAR2 in WB 和 EIA. Suitable for 人.
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Quick Overview for HCAR2 抗体 (Middle Region) (ABIN952597)
抗原
See all HCAR2 抗体
HCAR2
(Hydroxycarboxylic Acid Receptor 2 (HCAR2))
适用
人
宿主
兔
克隆类型
多克隆
标记
This HCAR2 antibody is un-conjugated
应用范围
Western Blotting (WB), Enzyme Immunoassay (EIA)
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抗原表位
- AA 207-236, Middle Region
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特异性
- This antibody recognizes Human GRP109A (Center). Other species not tested.
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纯化方法
- Protein A column, followed by peptide affinity purification
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免疫原
- KLH conjugated synthetic peptide between 207-236 amino acids from the Central region of human GPR109A Genename: NIACR1
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亚型
- Ig Fraction
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibody
HCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 200-228) antibodyHCAR2 适用: 人 WB 宿主: 兔 Polyclonal RB31358 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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别名
- GPR109A
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背景
- NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamideSynonyms: G-protein coupled receptor 109A, G-protein coupled receptor HM74A, HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag
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分子量
- 41850 Da
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基因ID
- 338442
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NCBI登录号
- NP_808219
抗原
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