HCAR2 抗体 (AA 260-340)
Our Local Distributor
北京 101111
Quick Overview for HCAR2 抗体 (AA 260-340) (ABIN7228866)
抗原
See all HCAR2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 260-340
-
原理
- Rabbit Anti-HCAR2 Polyclonal Antibody
-
特异性
- The antibody detects endogenous levels of HCAR2 protein
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthesized peptide derived from part region of human HCAR2 protein at AA range: 260-340
-
亚型
- IgG
-
-
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody
HCAR2 适用: 小鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibodyHCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 250-350) antibodyHCAR2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 200-228) antibodyHCAR2 适用: 人 WB 宿主: 兔 Polyclonal RB31358 unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody (FITC)HCAR2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
有效期
- 12 months
-
-
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
-
别名
- HCAR2
-
背景
- Hydroxycarboxylic acid receptor 2, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, Niacin receptor 1, Nicotinic acid receptorActs as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
-
分子量
- 39kD
-
基因ID
- 338442
-
UniProt
- Q8TDS4
抗原
-
