WB: 0.5 µg/mL Optimal conditions should be determined by the investigator.
限制
仅限研究用
状态
Lyophilized
溶解方式
Reconstitute with sterile PBS.
浓度
Lot specific
缓冲液
Lyophilized from a 0.2 µm filtered solution in PBS with 5 % trehalose.
注意事项
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
储存条件
4 °C/-20 °C
储存方法
Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
PPP3RL antibody, BcDNA:RH11383 antibody, CG4209 antibody, CNB antibody, Can antibody, CnB antibody, Dmel\\CG4209 antibody, canB-4F antibody, dCnB1 antibody, Cnb antibody, Cblp antibody, CaNB2 antibody, protein phosphatase 3 regulatory subunit B, beta antibody, Calcineurin B antibody, calcineurin B antibody, protein phosphatase 3, regulatory subunit B, beta antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) antibody, PPP3R2 antibody, CanB antibody, Cnb antibody, Ppp3r2 antibody, PPP3R1 antibody
背景
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus. Synonyms: Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody.