MRGPRX1/3/4 (AA 21-120) 抗体 (Alexa Fluor 647)
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- 抗原
- MRGPRX1/3/4
- 抗原表位
- AA 21-120
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- Alexa Fluor 647
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应用范围
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 特异性
- This may preferentially target MRGPRX1 over 3 and 4 due to slightly higher sequence similarity.
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human MRGX1
- 亚型
- IgG
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anti-MRGPRX1/3/4 (AA 21-120) antibody
适用: 人 IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- MRGPRX1/3/4
- 背景
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Synonyms: MRGPRC, G protein coupled receptor MRGX1, G protein coupled receptor SNSR3, GPCR, Mas related G protein coupled receptor member X1, MAS related gene MRGX1, MAS related GPR member X1, MRGPRX1, MRGX1, Sensory neuron specic G protein coupled receptor 3/4, Seven transmembrane helix receptor, SNSR3, SNSR4, MRGX1_HUMAN, MRGPRX3, MRGX3, MRGPRX4, MRGX4, SNSR5, SNSR6, SNSR1, SNSR2.
Background: There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
- 基因ID
- 259249, 117195, 117196
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