LSD1 抗体 (AA 101-200) (Alexa Fluor 647)
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- 抗原 See all LSD1 (KDM1A) 抗体
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
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抗原表位
- AA 101-200
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LSD1 antibody is conjugated to Alexa Fluor 647
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Cow,Pig,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human KDM1A
- 亚型
- IgG
- Top Product
- Discover our top product KDM1A Primary Antibody
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KDM1A 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibodyKO Validated KDM1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibodyKDM1A 适用: 人, 小鼠, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1H2F8 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibodyKDM1A 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9D2 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibodyKDM1A 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9A3 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibodyKDM1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibodyKDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibodyKDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852), (C-Term) antibodyKDM1A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7583 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibodyKDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
- 别名
- KDM1A (KDM1A 产品)
- 别名
- AOF2 antibody, BHC110 antibody, KDM1 antibody, LSD1 antibody, 1810043O07Rik antibody, AA408884 antibody, Aof2 antibody, D4Ertd478e antibody, Kdm1 antibody, Lsd1 antibody, mKIAA0601 antibody, DKFZp459N2450 antibody, RGD1562975 antibody, aof2 antibody, kdm1 antibody, wu:fb82e06 antibody, wu:fc51a02 antibody, wu:fj36a05 antibody, wu:fj66b06 antibody, KDM1A antibody, lsd1 antibody, xLSD1 antibody, AtLSD1 antibody, F9F13.30 antibody, F9F13_30 antibody, LESION SIMULATING DISEASE antibody, LESION SIMULATING DISEASE 1 antibody, lysine demethylase 1A antibody, lysine (K)-specific demethylase 1A antibody, lysine (K)-specific demethylase 1a antibody, LSD1 zinc finger family protein antibody, KDM1A antibody, Kdm1a antibody, kdm1a antibody, LSD1 antibody
- 背景
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Synonyms: AOF2, KDM1, LSD1, BHC110, Lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, KDM1A, KIAA0601
Background: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
- 基因ID
- 23028
- UniProt
- O60341
- 途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
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