Human Papilloma Virus 33 E6 (HPV-33 E6) (AA 51-149) 抗体 (Cy7)
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- 抗原
- Human Papilloma Virus 33 E6 (HPV-33 E6)
- 抗原表位
- AA 51-149
- 适用
- Alphapapillomavirus, Human Papillomavirus (HPV), Virus
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- Cy7
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 特异性
- This antibody will detect E6 in HPV33, HPV58, and Alphapapillomavirus 9.
- 交叉反应
- Virus
- 交叉反应 （详细）
- HPV33, HPV58, Alphapapillomavirus 9.
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human HPV33 E6 protein
- 亚型
- IgG
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anti-Human Papilloma Virus 33 E6 (HPV-33 E6) (AA 51-149) antibody
HPV-33 E6 适用: Alphapapillomavirus, Human Papillomavirus (HPV), Virus WB, IF (cc), IF (p), IHC (p), ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Human Papilloma Virus 33 E6 (HPV-33 E6)
- 别名
- HPV33 E6
- 物质类
- Viral Protein
- 背景
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Synonyms: E6 protein [Human papillomavirus type 33], Human Papilloma Virus, Human papillomavirus type 33, Human papillomavirus type 33, Protein 33, HPV33-E6 protein, HPV33 E6 protein, VE6_HPV33.
Background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
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