人 Papilloma Virus 16 E6 (HPV-16 E6) (AA 85-158) 抗体 (Alexa Fluor 555)
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- 抗原
- Human Papilloma Virus 16 E6 (HPV-16 E6)
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抗原表位
- AA 85-158
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适用
- Human Papillomavirus 16 (HPV-16), Virus, 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- Alexa Fluor 555
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应用范围
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, Virus
- 交叉反应 （详细）
- HPV16
- 纯化方法
- Purified by Protein A.
- 免疫原
- synthetic peptide from HPV16-E6 conjugated to KLH
- 亚型
- IgG
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anti-Human Papilloma Virus 16 E6 (HPV-16 E6) (AA 85-158) antibody
HPV-16 E6 适用: Human Papillomavirus 16 (HPV-16), Virus, 人 IF (p), ELISA, IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Human Papilloma Virus 16 E6 (HPV-16 E6) (AA 85-158) antibodyHPV-16 E6 适用: Human Papillomavirus 16 (HPV-16), Virus IF (p), IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated
anti-Human Papilloma Virus 16 E6 (HPV-16 E6) (AA 1-158) antibodyHPV-16 E6 适用: Human Papillomavirus (HPV) ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Human Papilloma Virus 16 E6 (HPV-16 E6)
- 别名
- HPV16 E6 protein
- 物质类
- Viral Protein
- 背景
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Synonyms: E6, HPV16 E6 protein, Human Papilloma Virus, Human papillomavirus type 16 E6, Human papillomavirus type 16, Protein E6, E6 protein, HPV16 E6, HPV16-E6, VE6_HPV16.
Background: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
- 基因ID
- 1489078
- UniProt
- P03126
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