FGFR1/FGFR2 抗体 (pTyr463, pTyr466) (Alexa Fluor 488)
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- 抗原 See all FGFR1/FGFR2 products
- FGFR1/FGFR2 (FGFR1, FGFR2)
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抗原表位
- pTyr463, pTyr466
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FGFR1/FGFR2 antibody is conjugated to Alexa Fluor 488
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 特异性
- This phosphorylation site is found at Tyr463 in Human and Mouse FGFR1, and Tyr486 in Rat. It is highly conserved and is homologous to the Tyr466 phosphorylation site in Human and Mouse FGFR2, and the Tyr370 site in Rat FGFR2.
- 交叉反应
- 人, 大鼠
- 预测反应
- Mouse,Cow,Pig,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr463
- 亚型
- IgG
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anti-FGFR1, FGFR2 (pTyr463), (pTyr466) antibody
适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-FGFR1, FGFR2 (pTyr463), (pTyr466) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FGFR1, FGFR2 (Ser10) antibody适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FGFR1, FGFR2 (pTyr463), (pTyr466) antibody适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FGFR1, FGFR2 (Tyr463), (Tyr466) antibody适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- FGFR1/FGFR2 (FGFR1, FGFR2)
- Abstract
- FGFR1/FGFR2 产品
- 背景
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Synonyms: bFGF R, BFGFR, C FGR, CD 331, CD331, CD331 antigen, CEK, FGFBR, FGFR 1, Fibroblast growth factor receptor 1, FLG, FLG protein, FLJ14326, FLT 2, FLT2, Fms like tyrosine kinase 2, Fms related tyrosine kinase 2, Fms related tyrosine kinase 2 Pfefer syndrome, H2, H3, H4, H5, HBGFR, Heparin binding growth factor receptor, Hydroxyaryl protein kinase, KAL 2, KAL2, MFR, N SAM, N sam tyrosine kinase, Protein tyrosine kinase, Tyrosylprotein kinase, Basic fibroblast growth factor receptor 1.
Background: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
- 基因ID
- 2260, 2263
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