DNAJA3 抗体 (AA 101-200)
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- 抗原 See all DNAJA3 抗体
- DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))
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抗原表位
- AA 101-200
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DNAJA3 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TID1/HCA57
- 亚型
- IgG
- Top Product
- Discover our top product DNAJA3 Primary Antibody
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anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) (AA 86-184) antibody
DNAJA3 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) (AA 1-480) antibodyDNAJA3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) (AA 1-446) antibodyDNAJA3 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) (AA 221-480) antibodyDNAJA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) (Center) antibodyDNAJA3 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3) antibodyDNAJA3 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3 (DNAJA3))
- 别名
- HCA57 (DNAJA3 产品)
- 别名
- Tid-1 antibody, 1200003J13Rik antibody, 1810053A11Rik antibody, C81173 antibody, Tid1l antibody, HCA57 antibody, TID1 antibody, hTID-1 antibody, DnaJ heat shock protein family (Hsp40) member A3 antibody, Dnaja3 antibody, DNAJA3 antibody
- 背景
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Synonyms: DnaJ Hsp40 homolog subfamily A member 3, DnaJ homolog subfamily A member 3 mitochondrial precursor, DnaJ protein Tid 1, DnaJ protein Tid1, HCA57, Hepatocellular carcinoma associated antigen 57, Highly similar to HYPOTHETICAL 105.9 KD PROTEIN F22B7.5 IN CHROMOSOME, hTid 1, hTid1, III [Caenorhabditis elegans], TID1, Tumorous imaginal discs Drosophila homolog, Tumorous imaginal discs protein Tid56 homolog, DNJA3_HUMAN.
Background: TID1 is a human homolog of the Drosophila tumor suppressor lethal tumerous imaginal discs and encodes two mitochondrial matrix localized splice variants of human Tid1 designated hTid1S and hTid1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid1L increases apoptosis induced by DNA damaging agents as mitomycin C and TNF alpha. A J domain mutant of hTid1L can dominantly suppress apoptosis and in sharp contrast the J domain mutant of hTid1S increases apoptosis. Expression of hTid1S and hTid1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti and pro apoptotic effects through discrete substrates and activities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.
- 基因ID
- 9093
- 途径
- Synaptic Membrane, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity
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