The antibody detects endogenous level of total GRASP protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 814-818 (Q-E-I-V-R ) derived from Rat GRASP. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
GRASP antibody, tamalin antibody, TAMALIN antibody, general receptor for phosphoinositides 1 associated scaffold protein antibody, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein antibody, GRASP antibody, grasp antibody, Grasp antibody
背景
GRASP (GRP1-associated scaffold protein, tamalin) is a 395 amino acid protein encoded by the human gene GRASP . GRASP is a scaffold protein that com-prises multiple protein-interacting domains, including a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain, a leucine-zipper region and a carboxyl-terminal PDZ-binding motif. GRASP is involved with intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses. GRASP forms a heteromer composed of GRASP , PSCD2 and at least one mGluR-1. It also interacts with PSCD3, mGluR-2, mGluR-3 and mGluR-5. GRASP is highly expressed in brain and has lower levels of expression in lung, heart, embryo, kidney and ovary.