The antibody detects endogenous levels of total ASPSCR1 protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 303-307 (P-Q-Q-E-Q) derived from Human ASPSCR1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.