The antibody detects endogenous level of total Fas protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 323-327 (E-N-S-N-F) derived from human Fas . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).