Phospholipase C gamma 2 抗体 (pTyr759)
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Quick Overview for Phospholipase C gamma 2 抗体 (pTyr759) (ABIN8123767)
抗原
See all Phospholipase C gamma 2 (PLCG2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr759
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原理
- PLCγ2 (Phospho Tyr759) Antibody
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特异性
- This antibody detects endogenous levels of Human Mouse PLCγ2 (phospho-Tyr759)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized phosho peptide around human PLCgamma2 (Tyr759)
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亚型
- IgG
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应用备注
- WB 1:500-2000, IF ICC 1:50-200,ELISA 1:2000-20000,IHC 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Phospholipase C gamma 2 (PLCG2)
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别名
- PLCgamma2
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背景
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Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)
Background: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],
Gene Name: PLCG2
Protein Name: PLCγ2 (Tyr759)
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基因ID
- 5336
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UniProt
- P16885
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途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades, VEGF Signaling, BCR Signaling
抗原
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