ICOSLG 抗体 (AA 201-250)
Our Local Distributor
北京 101111
Quick Overview for ICOSLG 抗体 (AA 201-250) (ABIN8122180)
抗原
See all ICOSLG 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 201-250
-
原理
- CD275 Antibody
-
特异性
- The antibody detects endogenous CD275
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- Synthetic peptide from human protein at AA range: 201-250
-
亚型
- IgG
-
-
-
-
应用备注
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
-
别名
- CD275
-
背景
-
Synonyms: ICOS ligand (B7 homolog 2, B7-H2, B7-like protein Gl50, B7-related protein 1, B7RP-1, CD antigen CD275)
Background: alternative products:Additional isoforms seem to exist,function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.,induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.,sequence caution:The sequence differs from that shown in position 300 onward for unknown reason.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.,
Gene Name: ICOSLG B7H2 B7RP1 ICOSL KIAA0653
Protein Name: ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
-
基因ID
- 23308
-
UniProt
- O75144
-
途径
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
-