CTCF 抗体
Our Local Distributor
北京 101111
Quick Overview for CTCF 抗体 (ABIN8120295)
抗原
See all CTCF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- CTCF Rabbit mAb
-
特异性
- This antibody detects endogenous levels of CTCF protein.
-
纯化方法
- The antibody was purified by protein A affinity chromatography.
-
免疫原
- Recombinant protein (or fragment).
-
亚型
- IgG
-
-
-
-
应用备注
- WB, 1:2000-1:10000 | IHC, 1:2000-1:10000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid freeze / thaw cycles
-
储存条件
- -20 °C
-
储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
-
-
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
-
别名
- CTCF
-
背景
-
Synonyms: CTCF, Transcriptional repressor CTCF, 11-zinc finger protein, CCCTC-binding factor, CTCFL paralog
Background: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms&apos, tumors. Alternatively spliced transcript variants encoding different isoforms have been
Gene Name: CTCF
Protein Name: CTCF
-
基因ID
- 10664
-
UniProt
- P49711
抗原
-