BID 抗体 (Cleaved-Arg71)
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北京 101111
Quick Overview for BID 抗体 (Cleaved-Arg71) (ABIN8119994)
抗原
See all BID 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Cleaved-Arg71
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原理
- BID (Cleaved-Arg71) Antibody
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特异性
- This antibody detects endogenous levels of Human,Mouse BID (Cleaved-Arg71, protein was cleaved amino acid sequence between 71-72)
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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免疫原
- Synthesized peptide derived from human BID (Cleaved-Arg71)
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亚型
- IgG
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anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103) antibody
BID 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0957-RB0958 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) antibodyBID 适用: 人 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-130) antibodyBID 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-196) antibodyBID 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3F3-1A3 unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 1-195) antibodyBID 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) (AA 68-103) antibodyBID 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-BH3 Interacting Domain Death Agonist (BID) antibodyBID 适用: 人 WB, IF, IHC (p), IF (cc) 宿主: 小鼠 Monoclonal 9C7 unconjugated
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应用备注
- WB 1:1000-2000 ELISA 1:5000-20000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- BID (BH3 Interacting Domain Death Agonist (BID))
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别名
- BID
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背景
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Synonyms: BH3-interacting domain death agonist (p22 BID, BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID), BH3-interacting domain death agonist p13 (p13 BID), BH3-interacting domain death agonist p11 (p11 BID)]
Background: domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.,subcellular location:A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.,subcellular location:Associated with the mitochondrial membrane.,subcellular location:Translocates to mitochondria as an integral membrane protein.,subcellular location:When uncleaved, it is predominantly cytoplasmic.,subunit:Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2.,tissue specificity:Isoforms 2 and 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).,
Gene Name: BID
Protein Name: BID (Cleaved-Arg71)
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基因ID
- 637
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UniProt
- P55957
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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