ZEB1/2 抗体 (AA 211-320)
(3 references)-
- 抗原 See all ZEB1/2 products
- ZEB1/2 (ZEB1, ZEB2)
- 抗原表位
- AA 211-320
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZEB1/2 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), Flow Cytometry (FACS), ELISA
- 特异性
- Antibody will bind to Zinc finger E-box-binding homeobox 1 & 2
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Cow,Pig,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human ZEB1
- 亚型
- IgG
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." in: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).
: "ZEB1 Expression Is Correlated With Tumor Metastasis and Reduced Prognosis of Breast Carcinoma in Asian Patients." in: Cancer investigation, Vol. 33, Issue 6, pp. 225-31, (2015) (PubMed).
: "Significance of epithelial growth factor in the epithelial-mesenchymal transition of human gallbladder cancer cells." in: Cancer science, Vol. 103, Issue 6, pp. 1165-71, (2012) (PubMed).
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: "The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation." in: International journal of molecular sciences, Vol. 16, Issue 7, pp. 16313-29, (2016) (PubMed).
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- 抗原
- ZEB1/2 (ZEB1, ZEB2)
- 别名
- ZEB1/2 (ZEB1/2 产品)
- 背景
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Synonyms: AREB 6, AREB6, BZP, Delta crystallin enhancer binding factor 1, DELTA EF1, FECD6, MGC133261, Negative regulator of IL 2, Negative regulator of IL2, NIL 2 A, NIL 2 A zinc finger protein, NIL 2A, NIL-2-A zinc finger protein, NIL2A, Posterior polymorphous corneal dystrophy 3, PPCD3, Represses interleukin 2 expression, TCF 8, TCF-8, TCF8, Transcription factor 8 represses interleukin 2 expression, Transcription factor 8, ZEB 1, ZEB, ZEB1, ZEB1_HUMAN, ZFHEP, ZFHX 1A, ZFHX1A, Zinc finger E box binding homeobox 1, Zinc finger E-box-binding homeobox 1, Zinc finger homeodomain enhancer binding protein, Smad Interacting Protein 1 SIP 1, SIP1 SIP-1, Smad-interacting protein 1, SMADIP 1, SMADIP1, ZEB 2, ZEB2, ZEB2_HUMAN, Zfhx1b, ZFHX1B protein, Zfx1b, Zinc finger E box binding protein 2, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox 1b, zinc finger homeobox protein 1, Zinc finger homeobox protein 1b.
Background: ZEB1 Inhibits interleukin-2 (IL-2) gene expression. May be responsible for transcriptional repression of the IL-2 gene. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. ZEB2 is a Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
- 基因ID
- 6935, 9839
- UniProt
- P37275, O60315
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