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ATG4D 抗体 (AA 381-474) (Cy7)

This anti-ATG4D antibody (ABIN752479) is a Rabbit Polyclonal antibody detecting ATG4D in WB, IF (cc), IF (p). Suitable for Mouse.
产品编号 ABIN752479
发货至: 中国

Quick Overview for ATG4D 抗体 (AA 381-474) (Cy7) (ABIN752479)

抗原

See all ATG4D 抗体
ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

适用

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小鼠

宿主

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克隆类型

  • 68
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多克隆

标记

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This ATG4D antibody is conjugated to Cy7

应用范围

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Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

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    AA 381-474

    交叉反应

    小鼠

    预测反应

    Human,Rat,Dog,Cow,Pig

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human ATG4D

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))

    别名

    ATG4D

    背景

    Synonyms: APG4D, AUTL4, APG4-D, Cysteine protease ATG4D, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, ATG4D

    Background: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

    基因ID

    84971

    UniProt

    Q86TL0

    途径

    Autophagy
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