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IGF1R 抗体 (AA 44-960) (Biotin)

Name: IGF1R 抗体 (AA 44-960) (Biotin)
SKU: ABIN7999977
Availability: OutOfStock

The 兔多克隆 anti-IGF1R antibody is suitable to detect IGF1R in samples from 人. It has been validated for WB, IHC 和 ELISA.

产品编号 ABIN7999977

发货至: 中国

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Quick Overview for IGF1R 抗体 (AA 44-960) (Biotin) (ABIN7999977)

抗原

See all IGF1R 抗体

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

适用

人

宿主

兔

克隆类型

多克隆

标记

This IGF1R antibody is conjugated to Biotin

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Discover our top product IGF1R Primary Antibody

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AA 44-960

原理

Anti-IGF1R Antibody Biotin Conjugated

预测反应

Human IGF1R shares 95.9%,95.8% amino acid (aa) sequence identity with mouse,rat IGF1R,respectively.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human IGF1R recombinant protein (Position: Q44-R960). Human IGF1R shares 95.9% and 95.8% amino acid (aa) sequence identity with mouse and rat IGF1R, respectively.

亚型

IgG
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 251-350) antibody
IGF1R 适用: 人, 小鼠, 大鼠, 犬 FACS 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1165), (pTyr1166) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1161) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77), (N-Term) antibody
IGF1R 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB15292 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibody
IGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77) antibody
IGF1R 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibody
IGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

限制

仅限研究用
状态

Liquid

缓冲液

Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

有效期

12 months
抗原

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

别名

IGF1R

背景

Background: IGF1R(Insulin-like Growth Factor 1(IGF-1) Receptor) is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1(IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. The IGF1R gene is mapped on 15q26.3. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Using a yeast 2-hybrid system, Dey et al.(1998) identified a regulatory subunit of phosphatidylinositol(PI) 3-kinase, PIK3R3, as a binding partner of IGF1R. Functional interaction between BRCA1 and SP1 in the regulation of the IGF1R gene was studied in Schneider cells, a Drosophila cell line which lacks endogenous SP1. In these cells, BRCA1 suppressed 45 % of the SP1-induced trans-activation of the IGF1R promoter. Overexpression of the Grb10-binding fragment of Gigyf1 resulted in a significant increase in Igf1-stimulated Igf1r tyrosine phosphorylation. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. IGF-1 activates the Insulin receptor at approximately 0.1x the potency of insulin. Part of this signaling may be via IGF1R-InsulinReceptor heterodimers.
Gene Full Name: insulin like growth factor 1 receptor

基因ID

3480

UniProt

P08069

途径

RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy