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IGF1R 抗体 (pTyr1165, pTyr1166)

Name: IGF1R 抗体 (pTyr1165, pTyr1166)
SKU: ABIN6255780
Availability: OutOfStock

IGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of IGF1R phosphorylation expression in mouse brain tissue lysates,The lane on the right is treated with the antigen-specific peptide. (IGF1R 抗体 (pTyr1165, pTyr1166))

IF/ICC

ABIN6267335 at 1/200 staining Rat lung tissue sections by IHC-P. (IGF1R 抗体 (pTyr1165, pTyr1166))

IHC

Western blot analysis of IGF1R phosphorylation expression in Insulin treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (IGF1R 抗体 (pTyr1165, pTyr1166))

4 images

(1 reference)

产品编号 ABIN6255780

发货至: 中国

Datasheet as PDF

抗原 See all IGF1R 抗体

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
抗原表位
26

23

23

14

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11

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10

7

6

6

5

5

5

5

4

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3

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2

2

2

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2

2

2

2

2

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2

1

1

1

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pTyr1165, pTyr1166
适用
188

116

97

16

7

7

6

3

3

2

2

2

1

1

1
人, 小鼠, 大鼠
宿主
175

27

2

1
兔
Compatible Secondaries
克隆类型
177

28
多克隆
标记
119

9

8

7

7

7

7

7

7

7

4

3

3

3

3

3

2
This IGF1R antibody is un-conjugated
应用范围
126

67

58

54

32

25

17

13

13

9

5

4

4

3

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-IGF1 Receptor (Tyr1165/Tyr1166) Antibody detects endogenous levels of IGF1 Receptor only when phosphorylated at Tyrosine 1165/Tyrosine 1166.

预测反应

Bovine,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human IGF1 Receptor around the phosphorylation site of Tyr1165/Tyr1166.

亚型

IgG

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anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1161) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77) antibody
IGF1R 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibody
IGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1101-1367) antibody
IGF1R 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3G5C1 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibody
IGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (Tyr1346) antibody
IGF1R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhu, Wu, Huang, Zhong: "Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways." in: Toxicology letters, Vol. 272, pp. 75-83, (2017) (PubMed).
抗原

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

别名

IGF1R (IGF1R 产品)

别名

CMT2N antibody, CD221 antibody, IGFIR antibody, IGFR antibody, JTK13 antibody, IGFIRC antibody, IGFR1 antibody, IGF-1R antibody, IGF1R antibody, DKFZp469I0618 antibody, igf-1r antibody, xIGF-1R antibody, xIGFR antibody, xigf1r antibody, A330103N21Rik antibody, D930020L01 antibody, hyft antibody, igf-ir antibody, IGF-IR antibody, IGF-IRb antibody, wu:fb03h06 antibody, IGF-IRa antibody, sb:eu1090 antibody, wu:fi20b10 antibody, alanyl-tRNA synthetase antibody, insulin like growth factor 1 receptor antibody, insulin-like growth factor 1 receptor antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I receptor antibody, insulin like growth factor 1 receptor S homeolog antibody, insulin-like growth factor 1b receptor antibody, insulin-like growth factor 1a receptor antibody, AARS antibody, IGF1R antibody, Igf1r antibody, igf1r antibody, Igf1 antibody, LOC780503 antibody, LOC100136427 antibody, igf1r.S antibody, igf1rb antibody, igf1ra antibody

背景

Description: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.
Gene: IGF1R

分子量

90,155kDa

基因ID

3480

UniProt

P08069

途径

RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy