MCL-1 抗体 (AA 1-350)
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北京 101111
Quick Overview for MCL-1 抗体 (AA 1-350) (ABIN7999379)
抗原
See all MCL-1 (MCL1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 1-350
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原理
- Anti-MCL1 Antibody
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- Human MCL1 shares 82%,78% amino acid (aa) sequences identity with mouse,rat MCL1,respectively.
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产品特性
- Anti-MCL1 Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MCL1 recombinant protein (Position: M1-R350). Human MCL1 shares 82% and 78% amino acid (aa) sequences identity with mouse and rat MCL1, respectively.
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亚型
- IgG
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anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (Internal Region) antibody
MCL1 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 2-307) antibodyMCL1 适用: 小鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (Center) antibodyMCL1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (Internal Region) antibodyMCL1 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 1-350) antibodyMCL1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 191-226) antibodyMCL1 适用: 人, 小鼠, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB00961 unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) antibodyMCL1 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 8C6D4B1 unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 19-244) antibodyMCL1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 120-220) antibodyMCL1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1) (AA 6-328) antibodyMCL1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, RatWestern blot, 0.1-0.5 μg/mL, Human, Rat
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
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别名
- MCL1
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背景
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Background: MCL1, also known as myeloid cell leukemia 1, is a protein that in humans is encoded the MCL1 gene. It is mapped to 1q21.3. MCL1 is a potent multidomain antiapoptotic protein of the BCL2 family that heterodimerizes with other BCL2 family members to protect against apoptotic cell death. MCL1 as an attractive candidate for regulation of hematopoietic stem cell homeostasis that is highly expressed in hematopoietic stem cells and regulated by growth factor signals. MCL1 is a critical and specific regulator essential for ensuring the homeostasis of early hematopoietic progenitors. During mitotic arrest, MCL1 protein levels decline markedly, through a posttranslational mechanism, potentiating cell death. Phosphorylation of MCL1 s its interaction with the tumor suppressor protein FBW7, which is the substrate-binding component of a ubiquitin ligase complex.
Gene Full Name: MCL1 apoptosis regulator, BCL2 family member
Sequence Similarities: Belongs to the Bcl-2 family.
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分子量
- 37 kDa
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基因ID
- 4170
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UniProt
- Q07820
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途径
- MAPK Pathway
抗原
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