Axin 抗体 (AA 1-811) (Fluoro488)
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Quick Overview for Axin 抗体 (AA 1-811) (Fluoro488) (ABIN7971705)
抗原
See all Axin (AXIN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-811
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原理
- Anti-AXIN1 Antibody Fluoro488 Conjugated
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预测反应
- Human AXIN1 shares 86.2%,82.8% amino acid (aa) sequence identity with mouse,rat AXIN1,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human AXIN1 recombinant protein (Position: M1-K811). Human AXIN1 shares 86.2% and 82.8% amino acid (aa) sequence identity with mouse and rat AXIN1, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- Axin (AXIN1) (Axin 1 (AXIN1))
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别名
- AXIN1
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背景
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Background: Axin-1 is a protein that in humans is encoded by the AXIN1 gene. This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
Gene Full Name: axin 1
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基因ID
- 8312
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UniProt
- O15169
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途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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