Adenosine A2a Receptor 抗体 (AA 144-410) (FITC)
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Quick Overview for Adenosine A2a Receptor 抗体 (AA 144-410) (FITC) (ABIN7966611)
抗原
See all Adenosine A2a Receptor (ADORA2A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 144-410
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原理
- Anti-ADORA2A Antibody FITC Conjugated
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human ADORA2A shares 76.8%,75.3% amino acid (aa) sequence identity with mouse,rat ADORA2A,respectively.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ADORA2A recombinant protein (Position: N144-G410). Human ADORA2A shares 76.8% and 75.3% amino acid (aa) sequence identity with mouse and rat ADORA2A, respectively.
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亚型
- IgG
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应用备注
- Flow Cytometry, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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有效期
- 12 months
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- Adenosine A2a Receptor (ADORA2A)
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别名
- ADORA2A
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背景
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Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
Gene Full Name: adenosine A2a receptor
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基因ID
- 135
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UniProt
- P29274
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途径
- Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints
抗原
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