GTPase NRas 抗体
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Quick Overview for GTPase NRas 抗体 (ABIN7938429)
抗原
See all GTPase NRas (NRAS) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NRAS antibody (pAb)
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纯化方法
- Protein A Chromatography
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免疫原
- This information is proprietary to Active Motif and/or its suppliers.
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亚型
- IgG1
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anti-GTPase NRas (NRAS) (Internal Region) antibody
Verified NRAS 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-GTPase NRas (NRAS) (AA 72-101) antibodyNRAS 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-GTPase NRas (NRAS) (AA 72-101), (N-Term) antibodyNRAS 适用: 人, 大鼠, 小鼠 WB, FACS, IF 宿主: 兔 Polyclonal RB14459 unconjugated
anti-GTPase NRas (NRAS) (AA 101-189) antibodyNRAS 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-GTPase NRas (NRAS) (AA 147-179) antibodyNRAS 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-GTPase NRas (NRAS) (AA 91-140) antibodyNRAS 适用: 人, 大鼠, 小鼠, Cow, 马, 豚鼠, 兔, 斑马鱼, Bat, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-GTPase NRas (NRAS) antibodyNRAS 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-GTPase NRas (NRAS) antibodyNRAS 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB56819 unconjugated
anti-GTPase NRas (NRAS) (AA 90-189) antibodyNRAS 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A3 unconjugated
anti-GTPase NRas (NRAS) antibodyNRAS 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5G7 unconjugated
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应用备注
- *WB: 1 - 4 μg/mL dilution *For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.05 % Tween 20 to all blocking solutions may also reduce background. Individual optimization may be required.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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- GTPase NRas (NRAS)
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别名
- NRAS
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背景
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Background_Plain: Oncogenic mutations in Ras genes have been found in about 30 % of human cancers. This family of genes is involved in cell signaling pathways that control cell growth and death. The human Ras gene family consists of three identified members H-, K- and N-ras encoding proteins of 188-189 amino acids and 21,000 (p21) daltons. Human H- and K-ras are the homologues of v-H- and v-K-ras, sequences. Under normal circumstances the Ras-GTPase activity gradually converts GTP to GDP, but in oncogenic mutations Ras locks the protein into the active GTP conformation. This leads to a constant Ras gene and uncontrollable cell growth. Through signal transduction, NRAS is involved in regulating cells division. The information is received from outside the cell to the cell's nucleus to instruct the cell to proliferate, to mature or to differentiate. Due to these intracellular relationship Ras antibodies have emerged as a valuable tool for target validation studies for cancer.
Aliases: Neuroblastoma RAS Viral Oncogene Homolog, nras, Nras, NRAS
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分子量
- 21 kDa
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NCBI登录号
- NP_002515
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途径
- p53 Pathway, MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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