Neuregulin 1 抗体 (Extracellular, N-Term)
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Quick Overview for Neuregulin 1 抗体 (Extracellular, N-Term) (ABIN7885163)
抗原
See all Neuregulin 1 (NRG1) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 87-101, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Neuregulin-1
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预测反应
- Mouse,human - identical
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KIQKKPGKSELRINK, corresponding to amino acid residues 87-101 of human Neuregulin-1
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亚型
- IgG
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anti-Neuregulin 1 (NRG1) (AA 617-636), (C-Term) antibody
NRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (N-Term) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 198-229) antibodyNRG1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 221-320) antibodyNRG1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 1-241) antibodyNRG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal NRG1-2752 unconjugated
anti-Neuregulin 1 (NRG1) (AA 21-242) antibodyNRG1 适用: 人 IHC 宿主: 小鼠 Monoclonal NRG1-2710 unconjugated
anti-Neuregulin 1 (NRG1) antibodyNRG1 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuregulin 1 (NRG1) (AA 198-229) antibodyNRG1 适用: 人 FACS, IHC (p) 宿主: 兔 Polyclonal RB01275-01276 unconjugated
anti-Neuregulin 1 (NRG1) (AA 264-393) antibodyNRG1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236026)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW)
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Neuregulin 1 (NRG1)
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别名
- Glial growth factor
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背景
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Synonyms: Glial growth factor, GGF, Heregulin, HRG, Sensory and motor neuron derived factor, SMDF, Neu differentiation factor, NDF
Description: ErbB receptors are a family of tyrosine kinase receptors encoded by the erbB gene. These receptors commence signaling pathways such as the mitogen activated protein kinase (MAPK) and inositol 3-kinase (PI3K) pathways and have an important role in the control of cell growth and survival1. Neuregulins are a family of EGF-like factors that are produced from alternative RNA splicing of the same gene. Through their interaction with ErbB receptors, Neuregulins regulate normal developmental processes, plasticity, and oncogenesis2.Neuregulin-1 is one of the four known proteins of the Neuregulin family and can be found in many organs including the heart, breast, peripheral and central nervous system. Neuregulin-1 is encoded by a gene located on chromosome 8p13 which produces more than 15 different isoforms of the same protein. All isoforms contain a core EGF domain encoded by exon E130 but other elements of the protein vary. Most NRG1 isoforms are synthesized as transmembrane proproteins which undergo proteolytic cleavage processes3.Due to its important function in the central and peripheral nervous system as well as in other organs NRG1 has been implicated in a variety of pathologies. The NRG1 gene is suspected as a schizophrenia susceptibility gene. Mice with a mutated NRG1 exhibit elevated activity in open field and abnormal sensorimotor gating which correspond with schizophrenic like behavior in humans. These affects are reversed using anti-psychotic drugs4. In addition, Activation of NRG1 was found to improve cardiac survival and function in a rat and canine model of dilated and ischemic hearts5.
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基因ID
- 3084
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UniProt
- Q02297
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation
抗原
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