HLA-ABC 抗体
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北京 101111
Quick Overview for HLA-ABC 抗体 (ABIN7881087)
抗原
See all HLA-ABC 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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原理
- HLA-ABC Antibody (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- Human REH cells (a pre-B leukaemia cell line) was used as the immunogen for the HLA-ABC antibody.
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亚型
- IgG2a, kappa
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应用备注
- Optimal dilution of the HLA-ABC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the HLA-ABC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- HLA-ABC
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别名
- HLA-ABC
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背景
- Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Immunoprecipitation of lactoperoxidase radioiodinated cell surface proteins and surface sialoglycoproteins radiolabeled by sodium metaperiodate/tritiated sodium borohydride technique confirmed the structure gp44,p12 (consisting of a 44 kDa glycopeptide linked with a non-glycosylated 12 kDa peptide) typical for MHC class I antigen(s) as a structure recognized by Bra23/9. Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.
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UniProt
- P01889
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途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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