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HLA-ABC 抗体 (APC)

GMP Grade HLA-ABC 适用: 人, Baboon, Cynomolgus, 猕猴 FACS 宿主: 小鼠 Monoclonal W6-32 APC
产品编号 ABIN5067853
发货至: 中国
  • 抗原 See all HLA-ABC 抗体
    HLA-ABC
    适用
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    人, Baboon, Cynomolgus, 猕猴
    宿主
    • 57
    • 9
    • 3
    小鼠
    克隆类型
    • 59
    • 9
    单克隆
    标记
    • 31
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    This HLA-ABC antibody is conjugated to APC
    应用范围
    • 53
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    • 1
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    Flow Cytometry (FACS)
    产品特性
    Clone W6/32 recognizes a cell surface 45 kD non-polymorphic epitope protein shared among products of the HLA-A, B, and C loci. HLA class I antigen associated with beta 2-microglobulin are expressed by all human nucleated cells and HLA-Class I down regulation occurs frequently in many cancers which might adversely affect the clinical course of cancer and the outcome of T-cell-based immunotherapy. HLA-Class I present specific foreign antigen to CD8+ T cells which play central role against infection, tumor and also generation of autoimmune diseases.
    纯化方法
    Purified
    纯度
    >95 %
    质量等级
    GMP Grade
    免疫原
    Human Leukocytes
    克隆位点
    W6-32
    亚型
    IgG2a kappa
    Top Product
    Discover our top product HLA-ABC Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    HLA-ABC
    别名
    HLA-ABC (HLA-ABC 产品)
    别名
    HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody
    背景
    Clone W6/32 recognizes a cell surface 45 kD non-polymorphic epitope protein shared among products of the HLA-A, B, and C loci. HLA class I antigen associated with beta 2-microglobulin are expressed by all human nucleated cells and HLA-Class I down regulation occurs frequently in many cancers which might adversely affect the clinical course of cancer and the outcome of T-cell-based immunotherapy. HLA-Class I present specific foreign antigen to CD8+ T cells which play central role against infection, tumor and also generation of autoimmune diseases.
    途径
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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