GTPase NRas 抗体
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Quick Overview for GTPase NRas 抗体 (ABIN7880943)
抗原
See all GTPase NRas (NRAS) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- NRAS Antibody
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纯化方法
- Affinity purified
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免疫原
- A synthetic peptide specific to human NRAS was used as the immunogen for the NRAS antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the NRAS antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the NRAS antibody at -20oC.
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- GTPase NRas (NRAS)
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别名
- NRAS
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背景
- NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. It has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in the gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [RefSeq]
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UniProt
- P01111
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途径
- p53 Pathway, MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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