ROS1 抗体
Our Local Distributor
北京 101111
Quick Overview for ROS1 抗体 (ABIN7880120)
抗原
See all ROS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- ROS1 Antibody
-
纯化方法
- Protein G purified
-
免疫原
- Recombinant human ROS1 was used as the immunogen for the ROS1 antibody.
-
亚型
- IgG1, kappa
-
-
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the ROS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the ROS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))
-
别名
- ROS1
-
背景
- Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. [UniProt]
-
UniProt
- P08922
-
途径
- RTK signaling
抗原
-