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Nestin 抗体 (AA 698-844)

This 小鼠 单克隆 antibody specifically detects Nestin in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7876460
发货至: 中国
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Quick Overview for Nestin 抗体 (AA 698-844) (ABIN7876460)

抗原

See all Nestin (NES) 抗体
Nestin (NES)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Nestin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

NES-2911
  • 抗原表位

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    AA 698-844

    原理

    Nestin Antibody

    纯化方法

    Protein G affinity chromatography

    免疫原

    A recombinant human partial protein (amino acids 698-844) was used as the immunogen for the Nestin antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the Nestin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the Nestin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    Nestin (NES)

    别名

    Nestin

    背景

    Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. It is also a component of the dynamic IF network during muscle development, where it polymerizes with Desmin and Vimentin. Nestin co-assembles with Vimentin or -internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nml IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. During axon elongation of differentiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.

    UniProt

    P48681
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