ROCK1 抗体 (AA 601-833)
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Quick Overview for ROCK1 抗体 (AA 601-833) (ABIN7876067)
抗原
See all ROCK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 601-833
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原理
- Rho-associated protein kinase 1 Antibody / ROCK1
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids K601-R833) was used as the immunogen for the Rho-associated protein kinase 1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Rho-associated protein kinase 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Rho-associated protein kinase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
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别名
- Rho-associated protein kinase 1
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背景
- This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
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UniProt
- Q13464
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途径
- Microtubule Dynamics, WNT signaling, M Phase, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling
抗原
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