HLA-DRA 抗体 (AA 26-254)
Our Local Distributor
北京 101111
Quick Overview for HLA-DRA 抗体 (AA 26-254) (ABIN7872991)
抗原
See all HLA-DRA 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 26-254
-
原理
- HLA-DRA Antibody / HLA-DR
-
纯化方法
- Affinity purified
-
免疫原
- A human recombinant protein (amino acids I26-L254) was used as the immunogen for the HLA-DRA antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the HLA-DRA antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the HLA-DRA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- HLA-DRA (HLA Class II DR alpha (HLA-DRA))
-
别名
- HLA-DRA
-
背景
- HLA class II histocompatibility antigen, DR alpha chainis a protein that in humans is encoded by the HLA-DRA gene. It is mapped to 6p21.32. HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
-
UniProt
- P01903
-
途径
- TCR Signaling, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
-