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ICOSLG 抗体 (AA 23-149)

This 小鼠 单克隆 antibody specifically detects ICOSLG in ELISA 和 IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7872482
发货至: 中国
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Quick Overview for ICOSLG 抗体 (AA 23-149) (ABIN7872482)

抗原

See all ICOSLG 抗体
ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This ICOSLG antibody is un-conjugated

应用范围

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ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

ICOSL-3260
  • 抗原表位

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    AA 23-149

    原理

    ICOS Ligand Antibody / ICOS-L / B7RP-1 (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    A recombinant human partial protein (amino acids 23-149) was used as the immunogen for the ICOS Ligand antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the ICOS Ligand antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the ICOS Ligand antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

    别名

    ICOS Ligand

    背景

    This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

    UniProt

    O75144

    途径

    Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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