CFHR5 抗体 (AA 203-231)
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北京 101111
Quick Overview for CFHR5 抗体 (AA 203-231) (ABIN7872079)
抗原
See all CFHR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 203-231
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原理
- FHR-5 Antibody / Complement factor H-related protein 5 / CFHR5
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 203-231 from the human protein was used as the immunogen for the FHR-5 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the FHR-5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the FHR-5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- CFHR5 (Complement Factor H-Related 5 (CFHR5))
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别名
- FHR-5
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背景
- CFHR5 / FHR-5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq].
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UniProt
- Q9BXR6
抗原
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