TDG 抗体 (AA 15-370)
Our Local Distributor
北京 101111
Quick Overview for TDG 抗体 (AA 15-370) (ABIN7870789)
抗原
See all TDG 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 15-370
-
原理
- TDG Antibody / Thymine-DNA glycosylase
-
纯化方法
- Antigen affinity purified
-
免疫原
- E. coli-derived recombinant human protein (amino acids Q15-R370) was used as the immunogen for the TDG antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the TDG antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the TDG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- TDG (Thymine-DNA Glycosylase (TDG))
-
别名
- TDG
-
背景
- G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
-
UniProt
- Q13569
-
途径
- DNA Damage Repair, Chromatin Binding
抗原
-