Adenosine A2a Receptor 抗体 (AA 144-410)
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Quick Overview for Adenosine A2a Receptor 抗体 (AA 144-410) (ABIN7870718)
抗原
See all Adenosine A2a Receptor (ADORA2A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 144-410
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原理
- ADORA2A Antibody / Adenosine receptor A2A
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ADORA2A recombinant protein (Position: N144-G410) was used as the immunogen for the ADORA2A antibody.
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亚型
- IgG
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anti-Adenosine A2a Receptor (ADORA2A) (C-Term) antibody
ADORA2A 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 274-412) antibodyADORA2A 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 6A6G11 unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 1-412) antibodyADORA2A 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) antibodyADORA2A 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 165-300) antibodyADORA2A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 347-381), (C-Term) antibodyADORA2A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB52103 unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 147-267) antibodyADORA2A 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4E4 unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 1-412) antibodyADORA2A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (Internal Region) antibodyADORA2A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine A2a Receptor (ADORA2A) (AA 291-412) antibodyADORA2A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the ADORA2A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the ADORA2A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Adenosine A2a Receptor (ADORA2A)
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别名
- ADORA2A
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背景
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ADORA2A antibody recognizes Adenosine receptor A2A, a G protein-coupled receptor (GPCR) that mediates adenosine signaling to regulate neurotransmission, vascular tone, and immune responses. The ADORA2A gene, located on chromosome 22q11.23, encodes a seven-transmembrane domain receptor coupled to Gs proteins that stimulate cyclic AMP (cAMP) production upon adenosine binding. This receptor is highly expressed in the central nervous system, particularly in the striatum, as well as in immune cells, endothelial cells, and platelets.
Structurally, ADORA2A consists of an extracellular ligand-binding pocket for adenosine and intracellular domains that interact with G proteins and regulatory kinases. The receptor plays a critical role in modulating dopaminergic neurotransmission, motor control, and sleep regulation. Pharmacologically, ADORA2A is a therapeutic target for Parkinson's disease and psychiatric disorders due to its antagonistic interaction with dopamine D2 receptors. In the cardiovascular system, ADORA2A activation causes vasodilation and platelet inhibition, contributing to tissue perfusion and anti-thrombotic effects.
ADORA2A signaling also exerts immunomodulatory functions by suppressing pro-inflammatory cytokine production and promoting regulatory T cell activity. Dysregulation of this receptor is linked to neurodegenerative diseases, ischemia, and autoimmune conditions. Overexpression of ADORA2A in certain tumors supports immunosuppressive microenvironments by inhibiting T-cell activation, making it an emerging target for cancer immunotherapy. Structural and mutational analyses have revealed key residues responsible for ligand specificity and receptor desensitization through phosphorylation and arrestin binding.
Immunohistochemical staining using ADORA2A antibody shows membrane and cytoplasmic localization in neurons, endothelial cells, and lymphocytes. ADORA2A antibody from NSJ Bioreagents provides a powerful tool for studying adenosine-mediated signaling, neuroprotection, cardiovascular regulation, and tumor immunology. -
UniProt
- P29274
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途径
- Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints
抗原
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