SRRT 抗体 (AA 125-793)
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北京 101111
Quick Overview for SRRT 抗体 (AA 125-793) (ABIN7870381)
抗原
See all SRRT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-793
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原理
- SRRT Antibody / ARS2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human ARS2/SRRT recombinant protein (Position: H125-Q793) was used as the immunogen for the SRRT antibody.
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亚型
- IgG
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anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 1-796) antibody
SRRT 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (C-Term) antibodyVerified SRRT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 826-876) antibodySRRT 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 627-876) antibodySRRT 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 733-766) antibodySRRT 适用: 人, 斑马鱼 WB 宿主: 兔 Polyclonal RB53167 unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 878-910) antibodySRRT 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53166 unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 1-50) antibodySRRT 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Serrate RNA Effector Molecule Homolog (SRRT) (AA 54-81), (N-Term) antibodySRRT 适用: 人 WB 宿主: 兔 Polyclonal RB37036 unconjugated
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应用备注
- Optimal dilution of the SRRT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SRRT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SRRT (Serrate RNA Effector Molecule Homolog (SRRT))
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别名
- SRRT
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背景
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SRRT antibody detects Serrate RNA effector molecule homolog, also known as ARS2, encoded by the SRRT gene on chromosome 7q22.1. SRRT antibody is widely used in studies of RNA metabolism, microRNA processing, and transcriptional regulation. SRRT/ARS2 functions as a nuclear cap-binding complex (CBC)-associated factor, linking transcription termination with RNA processing. It is expressed across many tissues, with elevated levels in proliferating cells where RNA synthesis and processing are highly active.
Structurally, SRRT contains RNA-binding domains and conserved regions that mediate interactions with the cap-binding complex proteins CBP80 and CBP20. These interactions stabilize RNA transcripts and recruit processing machinery. SRRT also associates with the microprocessor complex component DROSHA, supporting microRNA biogenesis. Alternative splicing generates isoforms with distinct regulatory functions.
Functionally, SRRT/ARS2 acts as a multifunctional adaptor at the intersection of transcription and RNA processing. It coordinates transcription termination, 3' end formation, and maturation of non-coding RNAs. SRRT also regulates microRNA production by stabilizing pri-miRNA transcripts and facilitating their cleavage by the DROSHA-DGCR8 complex. Knockdown experiments reduce microRNA levels, impairing gene silencing and altering cell proliferation. Researchers use SRRT antibody to study RNA metabolism, transcription regulation, and microRNA biology.
Clinically, SRRT has been implicated in cancer and developmental disorders. Overexpression of SRRT supports tumor cell proliferation by enhancing RNA processing efficiency. Mutations or deletions of SRRT disrupt RNA maturation and contribute to developmental abnormalities. SRRT has also been linked to antiviral defense, where it regulates RNA stability during infection. NSJ Bioreagents provides SRRT antibody to support research in RNA biology, oncology, and developmental disease.
Experimentally, SRRT antibody is used in western blotting to detect the ~100 kDa protein, in immunofluorescence microscopy to study nuclear localization, and in immunohistochemistry to evaluate tissue-specific expression. Co-immunoprecipitation with SRRT antibody enables identification of RNA processing complexes and binding partners. -
UniProt
- Q9BXP5
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途径
- Notch Signaling, Stem Cell Maintenance
抗原
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