TP53BP1 抗体 (AA 1239-1972)
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Quick Overview for TP53BP1 抗体 (AA 1239-1972) (ABIN7870362)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1239-1972
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原理
- P53 binding protein 1 Antibody / 53BP1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids H1239-H1972) was used as the immunogen for the p53 binding protein 1 antibody.
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亚型
- IgG
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 574-773) antibody
TP53BP1 适用: 人 IHC, WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6B3E10 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyKD Validated TP53BP1 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB13320 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 IHC, WB, FACS, IP 宿主: 兔 Monoclonal BL-250-1H11 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1239-1972) antibodyTP53BP1 适用: 人 IHC, WB, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyTP53BP1 适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyKO Validated TP53BP1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1955-1972), (C-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 IHC, WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25), (pSer29) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the p53 binding protein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the p53 binding protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- P53 binding protein 1
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背景
- TP53BP1 (Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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