Recombinant HLA-ABC 抗体 (AA 100-300)
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Quick Overview for Recombinant HLA-ABC 抗体 (AA 100-300) (ABIN7869840)
抗原
See all HLA-ABC 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 100-300
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原理
- HLA-ABC Antibody / MHC I (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the HLA-ABC antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the HLA-ABC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the HLA-ABC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- HLA-ABC
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别名
- HLA-ABC
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背景
- Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.
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UniProt
- P01889
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途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
抗原
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