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Recombinant HLA-ABC 抗体 (AA 100-300)

The 兔 单克隆 anti-HLA-ABC antibody (Clone MHC-I-8366R) (ABIN7869838) specifically detects HLA-ABC in IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN7869838
发货至: 中国
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Quick Overview for Recombinant HLA-ABC 抗体 (AA 100-300) (ABIN7869838)

抗原

See all HLA-ABC 抗体
HLA-ABC

抗体类型

Recombinant Antibody

适用

  • 90
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宿主

  • 68
  • 17
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克隆类型

  • 80
  • 9
单克隆

标记

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This HLA-ABC antibody is un-conjugated

应用范围

  • 65
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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

MHC-I-8366R
  • 抗原表位

    • 7
    • 1
    • 1
    AA 100-300

    原理

    HLA-ABC Antibody / MHC I (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the HLA-ABC antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the HLA-ABC antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the HLA-ABC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    HLA-ABC

    别名

    HLA-ABC

    背景

    Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.

    UniProt

    P01889

    途径

    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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