ICOSLG 抗体 (AA 1-300)
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Quick Overview for ICOSLG 抗体 (AA 1-300) (ABIN7869127)
抗原
See all ICOSLG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-300
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原理
- B7RP-1 Antibody / ICOSLG
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment of human ICOSLG/B7RP-1 protein (within amino acids 1-300) was used as the immunogen for the B7RP-1 antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the B7RP-1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the B7RP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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别名
- B7RP-1
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背景
- This mAb recognizes a protein of 36 kDa, identified as ICOS-L, also called B7RP-1 or B7-related protein 1. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF Alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.
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UniProt
- O75144
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途径
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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