SPARC 抗体 (AA 1-200)
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Quick Overview for SPARC 抗体 (AA 1-200) (ABIN7868740)
抗原
See all SPARC 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- SPARC Antibody / Osteonectin (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 1-200 was used as the immunogen for the SPARC antibody.
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亚型
- IgG2c, kappa
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应用备注
- Optimal dilution of the SPARC antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the SPARC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))
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别名
- SPARC
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背景
- SPARC (for secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. It is identical to osteonectin, a protein important to bone calcification that is highly conserved between species. SPARC, which can be selectively expressed by the endothelium in response to certain types of injury, induces rounding in adherent endothelial cells in vitro. It regulates endothelial barrier function through F-Actin-dependent changes in cell shape, coincident with the appearance of intercellular gaps, which provide a paracellular pathway for extravasation of macromolecules.
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UniProt
- P09486
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途径
- Autophagy
抗原
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