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IGF1R 抗体 (AA 550-750)

This 小鼠单克隆 antibody specifically detects IGF1R in FACS 和 IF. It exhibits reactivity toward 人.

产品编号 ABIN7862981

发货至: 中国

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Quick Overview for IGF1R 抗体 (AA 550-750) (ABIN7862981)

抗原

See all IGF1R 抗体

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This IGF1R antibody is un-conjugated

应用范围

Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

IGF1R-4667

Discover our top product IGF1R Primary Antibody

抗原表位
22

22

19

14

12

12

10

10

6

6

5

5

5

4

4

4

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 550-750

原理

IGF1R / CD221 Antibody

特异性

Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into °™ and æ subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

纯化方法

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

免疫原

Recombinant fragment (around aa550-750) of human IGF1R protein (exact sequence is proprietary)

亚型

IgG2c, kappa
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 251-350) antibody
IGF1R 适用: 人, 小鼠, 大鼠, 犬 FACS 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1165), (pTyr1166) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1161) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77) antibody
IGF1R 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibody
IGF1R 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibody
IGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77), (N-Term) antibody
IGF1R 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB15292 unconjugated

anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibody
IGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
浓度

200 μg/mL

缓冲液

Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

有效期

24 months
抗原

IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

别名

IGF1R

背景

CD221 antigen, IGF 1 receptor, IGF 1R, IGFIR, IGFIRC, IGFR, Insulin like growth factor 1 receptor precursor, Insulin-like growth factor 1 receptor beta chain, JTK13, Soluble IGF1R variant 1, Soluble IGF1R variant 2
Human breast carcinoma or colon carcinoma.

分子量

130kDa (IGF-1R), 97kDa (IGF-1R), 200kDa (pro-IGF-1R)

基因ID

3480, 643120, 714012

UniProt

P08069

途径

RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy