Recombinant PAK1 抗体 (pThr212)
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Quick Overview for Recombinant PAK1 抗体 (pThr212) (ABIN7828437)
抗原
See all PAK1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pThr212
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原理
- Recombinant Phospho-PAK1 (Thr212) Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-P21-Activated Kinase 1 (PAK1) (AA 191-280) antibody
PAK1 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-P21-Activated Kinase 1 (PAK1) (Center) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 252-501) antibodyPAK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 1-240) antibodyPAK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (pThr212) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 401-430) antibodyPAK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (Ser204) antibodyPAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (Thr402), (Thr421), (Thr423) antibodyPAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (N-Term) antibodyPAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-P21-Activated Kinase 1 (PAK1) (AA 245-490) antibodyPAK1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-1:5000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- PAK1 (P21-Activated Kinase 1 (PAK1))
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别名
- PAK1
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背景
- PAK,PAK1,PAKalpha,ADRB2,Alpha PAK,Alpha-PAK,MGC130000,MGC130001,p21 activated kinase 1,p21 protein (Cdc42/Rac) activated kinase 1,p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related),p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog,p21-activated kinase 1,p65 PAK,p65-PAK,P68-PAK,PAK alpha,PAK-1,Paka,Protein kinase MUK2,Rac/p21-activated kinase,Serine/threonine-protein kinase PAK 1,STE20 homolog yeast,yeast),The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, control of phagocyte NADPH oxidase, and growth factor-induced neurite outgrowth. Several mechanisms that induce PAK activity have been reported. Binding of Rac/Cdc42 to the CRIB (or PBD) domain near the amino terminus of PAK causes autophosphorylation and conformational changes in PAK. Phosphorylation of PAK1 at Thr423 by PDK induces activation of PAK1. Several autophosphorylation sites have been identified, including Ser199 and Ser204 of PAK1, and Ser192 and Ser197 of PAK2. Because the autophosphorylation sites are located in the amino-terminal inhibitory domain, it has been hypothesized that modification in this region prevents the kinase from reverting to an inactive conformation. Research indicates that phosphorylation at Ser144 of PAK1 or Ser139 of PAK3 (located in the kinase inhibitory domain) affects kinase activity. Phosphorylation at Ser21 of PAK1 or Ser20 of PAK2 regulates binding with the adaptor protein Nck. PAK4, PAK5/7, and PAK6 have lower sequence similarity with PAK1-3 in the amino terminal regulatory region. Phosphorylation at Ser474 of PAK4, a site analogous to Thr423 of PAK1, may play a pivotal role in regulating the activity and function of PAK4. PAK family members are widely expressed, and often overexpressed in human cancer. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 61 kDa
Observed MW: 62 kDa The actual band is not consistent with the expectation.
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UniProt
- Q13153
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途径
- MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis
抗原
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