FAS 抗体
Our Local Distributor
北京 101111
Quick Overview for FAS 抗体 (ABIN7670775)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Recombinant Fas/TNFRSF6/CD95 Monoclonal Antibody(Capture)
-
纯化方法
- Protein A/G Purification
-
免疫原
- Recombinant Human Fas/TNFRSF6/CD95 protein expressed by E.coli
-
亚型
- IgG2a
-
-
-
-
应用备注
- ELISA Capture 2-8 μg/mL
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- Sterile PBS , pH 7.4
-
储存液
- Without preservative
-
注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
-
有效期
- 12 months
-
-
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
-
别名
- Fas/TNFRSF6/CD95
-
背景
- FASR,TNFRSF6,APO1,APT1,FAS1,FASTM,ALPS1A,FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.
-
UniProt
- P25445
-
途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
-