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HLAG 抗体

The 小鼠 单克隆 anti-HLAG antibody is suitable to detect HLAG in samples from 人. It has been validated for FACS.
产品编号 ABIN7670065
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HLAG 抗体 (ABIN7670065)

抗原

See all HLAG 抗体
HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This HLAG antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

克隆位点

MEM-G-11
  • 原理

    Purified Anti-Human HLA-G Antibody[MEM-G/11]

    亚型

    IgG1, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    ≥ 1 mg/mL

    缓冲液

    Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    avoid freeze / thaw cycles.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

    有效期

    12 months
  • 抗原

    HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))

    别名

    HLA-G

    背景

    HLA,MHC-G,HLA-G,HLA-G HLA-6.0 HLAG,HLA-G5,HLA-6.0,HLAG,alpha chain G,B2 microglobulin,class I,DADB-15K14.8,HLA 6.0,HLA class I histocompatibility antigen,HLA class I histocompatibility antigen alpha chain G,HLA class I molecule,HLA G,HLA G antigen,HLA G histocompatibility antigen class I G,HLA G3,HLA60,HLA-G histocompatibility antigen,Major histocompatibility complex class I G,MHC class I antigen,MHC class I antigen G,MHC G,TCA,T-cell A locus,HLA-G Antibody (4H84) is an IgG1 κ mouse monoclonal HLA-G antibody (also designated HLA major histocompatibility complex, class I, G antibody, human leukocyte antigen (HLA) G antibody, 45 kDa transmembrane class I human leukocyte antigen G antibody, chromosome 6p22 gene complex class 1G antibody, placenta trophoblast marker antibody, or fetal derived placental cell marker antibody) that detects the HLA-G protein of mouse, rat and human origin by WB, IP, IF and IHC(P). HLA-G Antibody (4H84) is available as both the non-conjugated anti-HLA-G antibody form, as well as multiple conjugated forms of anti-HLA-G antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain, and a non-covalently associated protein, β-2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.

    UniProt

    P17693

    途径

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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