JNK 抗体 (pThr183, pTyr185) (FITC)
Quick Overview for JNK 抗体 (pThr183, pTyr185) (FITC) (ABIN732375)
抗原
See all JNK (MAPK8) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pThr183, pTyr185
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交叉反应
 - 犬, 人, 小鼠, 兔, 大鼠
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预测反应
 - Cow,Pig
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纯化方法
 - Purified by Protein A.
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免疫原
 - KLH conjugated synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Thr183/Tyr185
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亚型
 - IgG
 
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应用备注
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                        FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 
                                            
限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 μg/μL
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缓冲液
 - Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
 - 12 months
 
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                                            : "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes."    in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, (2016)         (PubMed).        
 
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                                            : "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes."    in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, (2016)         (PubMed).        
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- JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
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别名
 - JNK1 , 2 , 3
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背景
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Synonyms: JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2, Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, Stress-activated protein kinase 1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8
Background: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
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基因ID
 - 5599
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UniProt
 - P45983
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途径
 - MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins
 
抗原
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