ICOSLG 抗体 (AA 23-149) (CF®647)
Quick Overview for ICOSLG 抗体 (AA 23-149) (CF®647) (ABIN7655268)
抗原
See all ICOSLG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 23-149
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原理
- ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target)(ICOSL/3260), CF647 conjugate
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产品特性
- This MAb recognizes a protein of 36 kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2. 4, 3. 0, and 7. 0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1. 1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 23-149)
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亚型
- IgG2b, kappa
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anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-249) antibody
ICOSLG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-149) antibodyICOSLG 适用: 人 WB, ELISA, IHC, FACS, IF, Coat, StM 宿主: 小鼠 Monoclonal ICOSL-3111 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1G6E1 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 58-249) antibodyICOSLG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 197-246) antibodyICOSLG 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 23-149) antibodyICOSLG 适用: 人 ELISA, IHC, Coat, StM, ISt 宿主: 小鼠 Monoclonal ICOSL-3260 unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-120) antibodyICOSLG 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 19-256) antibodyICOSLG 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (AA 20-302) antibodyICOSLG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E2 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: HL60, HuT78 and HUVEC cells. Prostate or Colon Carcinoma.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))
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别名
- B7RP-1
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背景
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Synonyms: B7 homolog 2 (B7H2), B7 like protein Gl50, B7 related protein 1 (B7RP1), CD275, CD275 antigen, GL50, ICOS LG, ICOS ligand (ICOSL), Inducible T cell co stimulator ligand, LICOS, Transmembrane protein B7 H2 ICOS ligand
Gene Symbol: ICOSLG
Tissue Expression: Myeloid cells
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分子量
- 36 kDa
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基因ID
- 23308
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UniProt
- O75144
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途径
- Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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