Recombinant Bcl-2 抗体 (CF®740)
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北京 101111
Quick Overview for Recombinant Bcl-2 抗体 (CF®740) (ABIN7649883)
抗原
See all Bcl-2 (BCL2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Bcl-2 (Apoptosis & Follicular Lymphoma Marker) (rBCL2/796), CF740 conjugate
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产品特性
- This antibody recognizes a protein of 25-26 kDa, identified as Bcl-2. This antibody shows no cross-reaction with Bcl-x or Bax proteins. Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability. Bcl-2 appears to function in a feedback loop system with caspases. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Expression of Bcl-2 inhibits programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human bcl-2 protein
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亚型
- IgG1, kappa
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anti-B-Cell CLL/lymphoma 2 (BCL2) (N-Term) antibody
BCL2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 118-165) antibodyBCL2 适用: 人 WB, IF, FACS, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 101-160) antibodyBCL2 适用: 人, 小鼠, 大鼠, 兔, Cow, 小鸡, Bacteria WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibodyBCL2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 75-110) antibodyBCL2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB04684 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibodyBCL2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D1 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibodyBCL2 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 100-D5 unconjugated
anti-B-Cell CLL/lymphoma 2 (BCL2) antibodyBCL2 适用: 人 WB, IHC 宿主: 兔 Monoclonal BCL2-2210R unconjugated Recombinant Antibody
anti-B-Cell CLL/lymphoma 2 (BCL2) antibodyKD Validated BCL2 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB675 unconjugated Recombinant Antibody
anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibodyBCL2 适用: 人 WB, FACS, IP, IHC (p), ICC, IHC (fro) 宿主: 小鼠 Monoclonal Bcl-2-100 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: A431, U937, Jurkat, K562, HL-60 or HeLa cells. Tonsil or follicular lymphomas.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % rBSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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别名
- Bcl-2
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背景
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Synonyms: Apoptosis regulator Bcl-2, B-cell CLL/lymphoma-2
Gene Symbol: BCL2
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分子量
- 25-26 kDa
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基因ID
- 596
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UniProt
- P10415
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途径
- MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
抗原
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