Nibrin 抗体 (C-Term)
Quick Overview for Nibrin 抗体 (C-Term) (ABIN7602793)
抗原
See all Nibrin (NBN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Anti-p95 NBS1 Antibody Picoband® (monoclonal, 5D7A1)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-p95 NBS1 Antibody Picoband® (monoclonal, 5D7A1) (ABIN7602793). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human p95 NBS1, different from the related mouse sequence by three amino acids, and from the related rat sequence by five amino acids.
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亚型
- IgG2a
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anti-Nibrin (NBN) (AA 467-615) antibody
NBN 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 7E4C2 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 8E7 unconjugated
anti-Nibrin (NBN) (AA 461-754) antibodyNBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A9 unconjugated
anti-Nibrin (NBN) (AA 461-754) antibodyNBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 6E11 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Nibrin (NBN) (AA 435-754) antibodyNBN 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nibrin (NBN) (AA 645-754) antibodyNBN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-Nibrin (NBN) antibodyKO Validated NBN 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Nibrin (NBN) (AA 714-745), (C-Term) antibodyNBN 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x6 cells, Human
1. "Atlas of Genetics and Cytogenetics in Oncology and Haematology - NBS1". 2. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, Petrini JH (May 1998). "The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response". Cell 93 (3): 477-86. 3. Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, Saar K, Beckmann G, Seemanová E, Cooper PR, Nowak NJ, Stumm M, Weemaes CM, Gatti RA, Wilson RK, Digweed M, Rosenthal A, Sperling K, Concannon P, Reis A (May 1998). "Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome". Cell 93 (3): 467-76. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Nibrin (NBN)
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别名
- NBN
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背景
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Synonyms: Apoptic death agonist antibody, Apoptotic death agonist antibody, Apoptotic death agonist BID antibody, BH3 interacting domain death agonist antibody, BH3 interacting domain death agonist p11 antibody, BH3 interacting domain death agonist p13 antibody, BH3 interacting domain death agonist p15 antibody, BH3-interacting domain death agonist p11 antibody, BID antibody, BID isoform ES (1b) antibody, BID isoform L (2) antibody, BID isoform Si6 antibody, BID_HUMAN antibody, Desmocollin type 4 antibody, FP497 antibody, Human BID coding sequence antibody, MGC15319 antibody, MGC42355 antibody, p11 BID antibody, p13 BID antibody, p15 BID antibody, p22 BID antibody
Tissue Specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
Background: p95 NBS1, also known as NBN or Nibrin, is a protein which in humans is encoded by the NBN gene. Nibrin is a protein associated with the repair of double strand breaks (DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to asMRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).
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分子量
- 95 kDa
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基因ID
- 4683
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UniProt
- O60934
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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